Iczer One is a gynoid created by the Cthulhu (also known as Cthulwulf), to be their guardian. However, when the Cthulhu were taken over by Big Gold, Iczer One was jettisoned. She arrived on Earth and somehow got wind of the coming invasion by the Cthulhu, now under Big Gold's command. She was therefore forced to defend the Earth against those she was created to protect. To do this, she needed a partner to help her use the Iczer Robo, a giant fighting mecha which is somehow connected to her (a connection so profound, that when Iczer Robo's arm was cut off, Iczer One lost the use of her own, corresponding arm).